New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia

Joint Authors

Perveen, Shagufta
Orfali, Raha

Source

Journal of Chemistry

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-08-06

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Chemistry

Abstract EN

The thermophilic fungus Penicillium species was isolated from Ghamiqa hot spring sediments in Saudi Arabia.

Extract of Penicillium species cultured on solid rice medium yielded two new compounds 3-(furan 12-carboxylic acid)-6-(methoxycarbonyl)-4-hydroxy-4-methyl-4 and 5-dihydro-2H-pyran 1 3α-methyl-7-hydroxy-5-carboxylic acid methyl ester-1-indanone 2.

In addition, three known compounds, austinol 3, emodin 4, and 2-methyl-penicinoline 5, were isolated.

The structures of the new compounds were unambiguously determined by comprehensive analysis of spectroscopic data, one- and two-dimensional NMR spectroscopy, and high-resolution mass spectrometry.

All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176.

Austinol 3 exhibited strong antibacterial activity against P.

aeruginosa bacterial strain with an MIC value of 0.13 ± 0.4 µg·mL−1, whereas emodin 4 demonstrated significant cytotoxicity against the tested HTB-176 cell line with an IC50 value of 2 ± 7.6 µM, while the other compounds were moderate to inactive with IC50 ranging from 4.3 ± 0.25–22 ± 2.94 µM in this assay.

American Psychological Association (APA)

Orfali, Raha& Perveen, Shagufta. 2019. New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1171555

Modern Language Association (MLA)

Orfali, Raha& Perveen, Shagufta. New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia. Journal of Chemistry No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1171555

American Medical Association (AMA)

Orfali, Raha& Perveen, Shagufta. New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1171555

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1171555