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Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse
Joint Authors
Li, Jianhui
Sun, Xiaohua
Yao, Danzhen
Xia, Jinying
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Antithyroid drug (ATD) treatment occupies the cornerstone therapeutic modality of Graves’ disease (GD) with a high relapse rate after discontinuation.
This study aimed to assess potential risk factors for GD relapse especially serum interleukin-17 (IL-17) expression.
Methods.
Consecutive newly diagnosed GD patients who were scheduled to undergo ATD therapy from May 2011 to May 2014 were prospectively enrolled.
Risk factors for GD relapse were analyzed by univariate and multivariate Cox proportional hazard analyses.
The association between serum IL-17 expression at cessation and GD relapse was analyzed with relapse-free survival (RFS) by the Kaplan–Meier survival analysis and log-rank test.
Results.
Of the 117 patients, 72 (61.5%) maintained a remission for 12 months after ATD withdrawal and 45 (38.5%) demonstrated GD relapse.
The final multivariate Cox analysis indicated elevated IL-17 expression at cessation to be an independent risk factor for GD relapse within 12 months after ATD withdrawal (HR: 3.04, 95% CI: 1.14–7.67, p=0.021).
Patients with higher expressions of IL-17 (≥median value) at cessation demonstrated a significantly higher RFS than those with lower levels by the Kaplan–Meier analysis and log-rank test (p=0.028).
Conclusions.
This present study indicated elevated serum IL-17 expression at cessation to be a predictor for GD relapse within 12 months.
American Psychological Association (APA)
Li, Jianhui& Sun, Xiaohua& Yao, Danzhen& Xia, Jinying. 2018. Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171574
Modern Language Association (MLA)
Li, Jianhui…[et al.]. Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse. International Journal of Endocrinology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1171574
American Medical Association (AMA)
Li, Jianhui& Sun, Xiaohua& Yao, Danzhen& Xia, Jinying. Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171574