Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant taiep Rat: An Animal Model of Demyelinating Diseases
Joint Authors
Eguibar, Jose R.
Muñoz-de-la-Torre, L. P.
Cortés, C.
Ugarte, A.
Trujillo, A.
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Infertility and reproductive problems have been reported in women with several neurological disorders, for example, demyelination.
However, the physiology of such problems has remained unknown so far.
The taiep rats are an animal neurological model that initially shows a hypomyelination followed by a progressive demyelination of the central nervous system.
This animal has reproductive problems, and the aim of this work is to characterize the follicular development, secretion of ovarian hormones, and presence of noradrenaline in the ovaries of the female taiep rats in the juvenile and adult stages.
The taiep rats have low body weight (approximately 19% less than that of SD rats), a delay of 4 days in the age of vaginal opening, and an irregularity in the estrous cycle by the absence or prolongation of some estral cycle stage.
In the juvenile stage, we observed a decrease of approximately 44% in the total number of follicles with a 15% increase of atresia and an 80% decrease in the fluorescence intensity of catecholamines in the ovaries, with a 21% increment in plasma concentrations of testosterone.
In the adult stage, we observed follicular cysts and a 50% decrease in fluorescence intensity of catecholamines in the ovaries, with changes in the secretion of ovarian hormones, an increase of 20 times in progesterone, and a decrement of a half in estradiol.
The demyelination in taiep rats affects follicular development and steroidogenesis in the early stages of the animal’s life, and this is maintained until adulthood.
American Psychological Association (APA)
Muñoz-de-la-Torre, L. P.& Eguibar, Jose R.& Cortés, C.& Ugarte, A.& Trujillo, A.. 2018. Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant taiep Rat: An Animal Model of Demyelinating Diseases. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171592
Modern Language Association (MLA)
Muñoz-de-la-Torre, L. P.…[et al.]. Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant taiep Rat: An Animal Model of Demyelinating Diseases. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1171592
American Medical Association (AMA)
Muñoz-de-la-Torre, L. P.& Eguibar, Jose R.& Cortés, C.& Ugarte, A.& Trujillo, A.. Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant taiep Rat: An Animal Model of Demyelinating Diseases. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171592