High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening
Joint Authors
Chen, Dubo
Feng, Pinning
Lin, Wenbin
Li, Yuzhe
Yao, Zhenrong
Xu, Hongxu
Chen, Yonghong
Xiao, Jiahao
Gan, Wenjia
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated.
The screening test for primary aldosteronism is benefit for minimizing damage to the patient.
In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemiluminescence assay, a newly developing method, and prompted its high efficiency in primary aldosteronism screening in upright position.
In this study, we want to evaluate its efficiency in practical work.
We used this ratio to continuously screen 238 patients, and 58 patients were finally diagnosed with primary aldosteronism.
We found it had 86.13% accuracy rate in the upright position compared with the final clinical diagnosis.
False negative and positive rates were 13.79% and 13.89%.
Diagnostic sensitivity and specificity were 86.21% and 86.11%, which are slightly different from results in our previous study.
False negative rate can be improved by combining the aldosterone-to-renin ratio with aldosterone concentration.
We also found impaired glucose tolerance may be a reason for high false positive rate.
Besides, chemiluminescence assay may be interfered in aldosterone detection.
Although it has some shortcomings, chemiluminescence assay-detected aldosterone-to-renin ratio is a highly effective index for screening primary aldosteronism in practice.
American Psychological Association (APA)
Lin, Wenbin& Li, Yuzhe& Chen, Dubo& Yao, Zhenrong& Xu, Hongxu& Chen, Yonghong…[et al.]. 2020. High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171626
Modern Language Association (MLA)
Lin, Wenbin…[et al.]. High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening. International Journal of Hypertension No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1171626
American Medical Association (AMA)
Lin, Wenbin& Li, Yuzhe& Chen, Dubo& Yao, Zhenrong& Xu, Hongxu& Chen, Yonghong…[et al.]. High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171626