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Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future
Joint Authors
Preechasuk, Lukana
Kunavisarut, Tada
Suwansaksri, Nattakarn
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hyperthyroidism is a common endocrine disease.
Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis.
Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice.
Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroid drugs.
NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine.
In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism.
In addition, we also describe the state-of-the-art in future drugs under development including rituximab, small-molecule ligands (SMLs), and monoclonal antibodies with a thyroid-stimulating hormone receptor (TSHR) antagonist effect.
American Psychological Association (APA)
Suwansaksri, Nattakarn& Preechasuk, Lukana& Kunavisarut, Tada. 2018. Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171667
Modern Language Association (MLA)
Suwansaksri, Nattakarn…[et al.]. Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1171667
American Medical Association (AMA)
Suwansaksri, Nattakarn& Preechasuk, Lukana& Kunavisarut, Tada. Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171667