Role of the Wntβ-Catenin Pathway in Renal Osteodystrophy
Joint Authors
Bisson, Sarah-Kim
Ung, Roth-Visal
Mac-Way, Fabrice
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients.
Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease.
Recently, sclerostin and Dickkopf-related protein 1 were suggested to play a significant role in CKD-related bone disease as they are known inhibitors of the Wnt pathway, thus preventing bone formation.
This review focuses on new knowledge about the Wnt pathway in bone, how its function is affected by chronic kidney disease and how this affects bone structure.
Expression of components and inhibitors of the Wnt pathway has been shown to be affected by the loss of kidney function, and a better understanding of the bone effects of Wnt pathway inhibitors could allow the development of new therapies to prevent bone fragility in this population.
American Psychological Association (APA)
Bisson, Sarah-Kim& Ung, Roth-Visal& Mac-Way, Fabrice. 2018. Role of the Wntβ-Catenin Pathway in Renal Osteodystrophy. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1171674
Modern Language Association (MLA)
Bisson, Sarah-Kim…[et al.]. Role of the Wntβ-Catenin Pathway in Renal Osteodystrophy. International Journal of Endocrinology No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1171674
American Medical Association (AMA)
Bisson, Sarah-Kim& Ung, Roth-Visal& Mac-Way, Fabrice. Role of the Wntβ-Catenin Pathway in Renal Osteodystrophy. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1171674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171674