Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort
Joint Authors
Lee, Jong Ho
Yoo, Hye Jin
Kim, Minjoo
Lee, Sang-Hyun
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammatory markers are susceptible to changes over time.
Thus, we observed changes in inflammatory markers correlating with age-related increases in blood pressure (BP) through a prospective study.
The aim of this study was to investigate changes in inflammatory markers that correlate with age-related increases in BP.
The study included 1,500 nondiabetic and normotensive healthy subjects at baseline.
Of these, 121 individuals who developed hypertension (defined as systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) after 2 years formed the hypertension group.
For each incident hypertension case, 2 age- and sex-matched control subjects were selected among those who did not develop hypertension (control group, n = 242).
After baseline adjustment, the hypertension group exhibited greater increases in body mass index (BMI), systolic and diastolic BP, triglyceride, total cholesterol, glucose, Lp-PLA2 activity, and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) levels compared to the control group.
In the hypertension group, changes in (Δ) systolic BP correlated positively with Δ Lp-PLA2 activity, which correlated positively with Δ low-density lipoprotein (LDL−) cholesterol and Δ urinary 8-epi-PGF2α levels.
Moreover, multiple linear regression revealed baseline systolic BP and Δ Lp-PLA2 activity to be independent predictors of Δ systolic BP in the hypertension group.
Our results suggest that age-related increases in systolic BP may correlate strongly with elevated Lp-PLA2 activity and that Lp-PLA2 can be considered a biomarker for systolic BP elevation.
American Psychological Association (APA)
Yoo, Hye Jin& Kim, Minjoo& Lee, Sang-Hyun& Lee, Jong Ho. 2020. Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171684
Modern Language Association (MLA)
Yoo, Hye Jin…[et al.]. Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171684
American Medical Association (AMA)
Yoo, Hye Jin& Kim, Minjoo& Lee, Sang-Hyun& Lee, Jong Ho. Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171684