![](/images/graphics-bg.png)
Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases
Joint Authors
Liu, Huan
Wang, Hongyu
Liu, Jinbo
Zhao, Hongwei
Wang, Kuanting
Huang, Wei
Zhao, Na
Li, Lihong
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The present study was done to investigate the relationship between carotid-femoral pulse wave velocity (CFPWV) and biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin (microalbumin) (UAE) in vascular-related diseases.
Methods.
656 subjects were enrolled into our study.
There were 377 patients with hypertension, 231 with coronary heart disease, 154 with diabetes mellitus, and 186 healthy subjects.
They were divided into four groups according to the number of suffered diseases: group 1 had only one of three diseases, group 2 had two, and group 3 had all of three diseases.
CFPWV was measured by Complior apparatus.
Results.
CFPWV was significantly higher in group 3 than in the healthy group, group 1, and group 2 (12.71 ± 2.38 vs 10.11 ± 2.28, 10.70 ± 2.12, and 11.92 ± 2.55, all p<0.05).
The level of Hcy was significantly higher in group1, group 2, and group 3 than in healthy subjects, respectively.
Levels of Log NT-proBNP and Log UAE were significantly higher in group 3 than in group 1 (2.27 ± 0.4 vs 2.10 ± 0.4, 1.00 ± 0.65 vs 0.68 ± 0.56, both p<0.05).
Positive correlation between CFWV and Hcy, Log UAE, and Log NT-proBNP was found in the entire study group (r = 0.109, 0.196, and 0.119, all p<0.05).
Multivariate analysis showed that pulse pressure, age, fasting plasma glucose, diastolic blood pressure, body mass index, and Log UAE were independent associating factors of CFPWV in all subjects (β = 0.334, p<0.001; β = 0.333, p<0.001; β = 0.126, p=0.004; β = 0.137, p=0.003; β = −0.142, p=0.002; and β = 0.098, p=0.031).
Conclusions.
CFPWV was significantly higher in subjects with hypertension, CHD, and DM.
There was correlation between CFPWV and biomarkers such as NT-proBNP, Hcy, and urine albumin (microalbumin).
American Psychological Association (APA)
Liu, Jinbo& Wang, Kuanting& Liu, Huan& Zhao, Hongwei& Huang, Wei& Zhao, Na…[et al.]. 2020. Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171725
Modern Language Association (MLA)
Liu, Jinbo…[et al.]. Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases. International Journal of Hypertension No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171725
American Medical Association (AMA)
Liu, Jinbo& Wang, Kuanting& Liu, Huan& Zhao, Hongwei& Huang, Wei& Zhao, Na…[et al.]. Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171725