HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis
Joint Authors
Zou, Yunzeng
Sun, Aijun
Ge, Junbo
Yu, Peng
Yu, Ying
Zhang, Lei
Jiang, Hong
Wu, Jian
Su, Yangang
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Fibrosis had important effects on pressure overload-induced left ventricular (LV) dysfunction.
High-mobility group box 1 (HMGB1), which was closely associated with fibrosis, was involved in the pressure overload-induced cardiac injury.
This study determines the role of HMGB1 in LV dysfunction under pressure overload.
Methods.
Transverse aortic constriction (TAC) operation was performed on male C57BL/6J mice to build the model of pressure overload, while HMGB1 or PBS was injected into the LV wall.
Cardiac function, collagen volume, and relevant genes were detected.
Results.
Echocardiography demonstrated that the levels of LV ejection fraction (LVEF) were markedly decreased on day 28 after TAC, which was consistent with raised collagen in the myocardium.
Moreover, we found that the exposure of mice to TAC + HMGB1 is associated with higher mortality, BNP, and collagen volume in the myocardium and lower LVEF.
In addition, real-time PCR showed that the expression of collagen type I, TGF-β, and MMP2 markedly increased in the myocardium after TAC, while HMGB1 overexpression further raised the TGF-β expression but not collagen type I and MMP2 expressions.
Conclusion.
This study indicated that exogenous HMGB1 overexpression in the myocardium aggravated the pressure overload-induced LV dysfunction by promoting cardiac fibrosis, which may be mediated by increasing the TGF-β expression.
American Psychological Association (APA)
Zhang, Lei& Yu, Ying& Yu, Peng& Wu, Jian& Sun, Aijun& Zou, Yunzeng…[et al.]. 2020. HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171745
Modern Language Association (MLA)
Zhang, Lei…[et al.]. HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis. International Journal of Hypertension No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171745
American Medical Association (AMA)
Zhang, Lei& Yu, Ying& Yu, Peng& Wu, Jian& Sun, Aijun& Zou, Yunzeng…[et al.]. HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171745