Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand
Joint Authors
Saleem, Shahul Hameed Sukkur
Sankarganesh, Murugesan
Jose, Paul Raj Adwin
Sakthikumar, Karunganathan
Raja, Jeyaraj Dhaveethu
Mitu, Liviu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]·nH2O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1H-NMR, FT-IR, UV-visible, and ESR techniques.
The electronic and ESR spectral data suggested that complexes 1–4 possess square planar geometry.
Antimicrobial activities of HL and complexes 1–4 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger).
These results show that complexes 1–4 have good antimicrobial activity compared to HL.
The DNA cleavage activity of HL and complexes 1–4 was monitored by the agarose gel electrophoresis method.
The antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.
DNA binding properties of HL and complexes 1–4 have been investigated by electronic absorption technique and viscometric measurements.
American Psychological Association (APA)
Saleem, Shahul Hameed Sukkur& Sankarganesh, Murugesan& Jose, Paul Raj Adwin& Sakthikumar, Karunganathan& Mitu, Liviu& Raja, Jeyaraj Dhaveethu. 2017. Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1171766
Modern Language Association (MLA)
Saleem, Shahul Hameed Sukkur…[et al.]. Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand. Journal of Chemistry No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1171766
American Medical Association (AMA)
Saleem, Shahul Hameed Sukkur& Sankarganesh, Murugesan& Jose, Paul Raj Adwin& Sakthikumar, Karunganathan& Mitu, Liviu& Raja, Jeyaraj Dhaveethu. Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1171766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171766