Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains
Joint Authors
Rizzo, Roberta
Bortolotti, Daria
Di Luca, Dario
Trapella, Claudio
Marchetti, Paolo
Zanirato, Vinicio
Alogna, Andrea
Gentili, Valentina
Sicolo, Mariangela
Turrin, Giulia
Fantinati, Anna
Bragonzi, Alessandra
Cervellati, Carlo
Giuseppe, Valacchi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pseudomonas aeruginosa is a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level.
During infection, P.
aeruginosa produces a well-organized bacterial structure, called biofilm, activating the quorum-sensing (QS) signaling, a mechanism of gene regulation.
In this work, we synthesized already known QS inhibitors (QSi) designed on the scaffold of the N-(3-oxododecanoyl) homoserine lactone (3O-C12-HSL) QS molecule and conjugated them with ciprofloxacin to inhibit P.
aeruginosa biofilm formation and increase the antibiotic susceptibility of clinical strains.
We identified, for the first time, a QSi conjugated with ciprofloxacin (ET37), that is able to reduce the formation of biofilm and the onset of tolerant clones in P.
aeruginosa clinical strains.
This compound could have a wide application in clinical setting.
The possibility to affect biofilm formation in chronically infected patients, such as patients affected by cystic fibrosis, and to reduce the onset of ciprofloxacin resistance would improve patient healing and allow to decrease antibiotic drug dosage.
American Psychological Association (APA)
Bortolotti, Daria& Trapella, Claudio& Bragonzi, Alessandra& Marchetti, Paolo& Zanirato, Vinicio& Alogna, Andrea…[et al.]. 2019. Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1171786
Modern Language Association (MLA)
Bortolotti, Daria…[et al.]. Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains. Journal of Chemistry No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1171786
American Medical Association (AMA)
Bortolotti, Daria& Trapella, Claudio& Bragonzi, Alessandra& Marchetti, Paolo& Zanirato, Vinicio& Alogna, Andrea…[et al.]. Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1171786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171786