Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus
Joint Authors
Khalil, Md. Ibrahim
Hossen, Md. Sakib
Gan, Siew Hua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products.
Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent.
Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ.
It has several important biological effects and has a relatively low toxicity.
Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways.
The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic β-cells.
Other possible mechanisms may involve stimulation of phospholipase A2, increase of glucose uptake, improving lipid profile, and/or reduction of inflammation.
This review summarizes the various sources, proteomics, biological roles, adverse effects, and medical applications of melittin and its mechanism of action in combating DM.
American Psychological Association (APA)
Hossen, Md. Sakib& Gan, Siew Hua& Khalil, Md. Ibrahim. 2017. Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1171788
Modern Language Association (MLA)
Hossen, Md. Sakib…[et al.]. Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1171788
American Medical Association (AMA)
Hossen, Md. Sakib& Gan, Siew Hua& Khalil, Md. Ibrahim. Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1171788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171788