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A Novel and Chemoselective Process of N-Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material
Joint Authors
González-González, Carlos A.
Vega, Juan Javier Mejía
Monroy, Ricardo García
González-Calderón, Davir
Corona-Becerril, David
Fuentes-Benítes, Aydeé
Mascarúa, Joaquín Tamariz
González-Romero, Carlos
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The process of N-alkylation of several pyrroles, indoles, and derivative heterocycles is herein described, using quaternary ammonium salts as the source of an alkylating agent.
These reactions were carried out on several heterocyclic rings with triethylbenzylammonium chloride or tetradecyltrimethylammonium bromide and an NaOH solution at 50%, leading to a chemoselective N-alkylated product and an average yield of 73%.
This is an alternative process to the traditional benzylation and methylation of N-heterocycles with direct handling of alkyl halides.
American Psychological Association (APA)
González-González, Carlos A.& Vega, Juan Javier Mejía& Monroy, Ricardo García& González-Calderón, Davir& Corona-Becerril, David& Fuentes-Benítes, Aydeé…[et al.]. 2017. A Novel and Chemoselective Process of N-Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171870
Modern Language Association (MLA)
González-González, Carlos A.…[et al.]. A Novel and Chemoselective Process of N-Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material. Journal of Chemistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1171870
American Medical Association (AMA)
González-González, Carlos A.& Vega, Juan Javier Mejía& Monroy, Ricardo García& González-Calderón, Davir& Corona-Becerril, David& Fuentes-Benítes, Aydeé…[et al.]. A Novel and Chemoselective Process of N-Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171870