Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract
Joint Authors
Source
International Journal of Inflammation
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acne is an inflammatory skin disorder; although some anti-inflammatory medicines for treating acne are available in a market, they have considerable side effects; therefore, new treatment options are needed.
In the present study, among the 16 aqueous extracts of plants collected from Jeju Island in Korea which are used to test anti-inflammatory activity, B.
davidii showed the strong decline of the proinflammatory cytokine expression against the inflammatory process caused by C.
acnes in Human HaCaT keratinocyte cells.
B.
davidii downregulated the expression of 57% of COX-2, 41% of iNOS, and proinflammatory cytokines 29% of TNF-α, 32% of IL-1β, 21% of IL-6, and 35% of IL-8.
Furthermore, B.
davidii inhibited NF-κB and MAPK signaling cascades in keratinocytes that activated by toll-like receptor 2 (TLR-2) in response to C.
acnes.
Given those results, B.
davidii is a potential agent to reduce the proinflammatory cytokine expression against C.
acnes-induced inflammation and might provide an alternative to the current medications.
American Psychological Association (APA)
Nguyen, Anh Thu& Kim, Ki-Young. 2020. Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract. International Journal of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171871
Modern Language Association (MLA)
Nguyen, Anh Thu& Kim, Ki-Young. Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract. International Journal of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171871
American Medical Association (AMA)
Nguyen, Anh Thu& Kim, Ki-Young. Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract. International Journal of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171871