Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis
Joint Authors
Saifei, Zhang
Yu, Xiaofang
Zhang, Long
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Euglycemic diabetic ketoacidosis (EDKA) was considered a rare condition with its specific definition and precipitating factors.
However, with the wide use of sodium glucose cotransporter 2 (SGLT-2) inhibitors, the newest class of antidiabetic agents, EDKA has come back into the spotlight.
Relevant cases are increasingly being reported along with insights into the mechanism of EDKA.
It seems increasingly clear that EDKA is more common than we used to believe.
The SGLT-2 inhibitor-associated EDKA also indicates a necessary review of our previous understanding of “diabetic” ketoacidosis, since the SGLT-2 inhibitor predisposes patients to DKA in a “starvation” way.
Actually, there are growing reports about starvation-induced ketoacidosis as well.
The previously “exclusive” nomenclature and cognition of these entities need to be reexamined.
That the hormonal interactions in DKA may differ from the severity of insulin deficiency also may have served in the scenario of EDKA.
The SGLT-2 inhibitors are newly approved in China.
The main purpose of this work is to have a better understanding of the situation and update our knowledge with a focus on the pathogenesis of EDKA.
American Psychological Association (APA)
Yu, Xiaofang& Saifei, Zhang& Zhang, Long. 2018. Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171885
Modern Language Association (MLA)
Yu, Xiaofang…[et al.]. Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171885
American Medical Association (AMA)
Yu, Xiaofang& Saifei, Zhang& Zhang, Long. Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171885