Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins
Joint Authors
Hamdi, N.
Mtibaa, Ahlem Chakchouk
Jelali, Hamida
Baklouti, Lasaad
Bilel, Hallouma
Bathich, Yaser
Mellouli, L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multicomponent cyclocondensation of hydrazine derivatives, ethyl acetoacetate, aromatic aldehydes, and 4-hydroxycoumarin has been reported.
The optimization details of the developed novel protocol are recorded.
The novel procedure features short reaction time, moderate yields, and simple workup.
In addition, BMIM[triflate] was chosen as a green solvent.
The structures of the obtained benzylpyrazolyl coumarins were determined and confirmed by 1H NMR, 13C NMR, IR, and elemental analysis.
The MIC values of benzylpyrazolyl coumarin derivatives were determined by the microbroth dilution method using 96-well plates.
However, the derivatives 5a, 5b, 5d, and 5g possess the strongest activities.
Compound 5b was the most active derivative against Candida albicans.
Moreover, the antioxidant activity determination of these coumarins derivatives 5(a–g)–6(a–g) were studied with the DPPH and compared with gallic acid (GA)and butylated hydroxytoluene (BHT).
Molecular modelling studies using DFT (density functional theory) calculations showed that there two tautomers A and B in which A is more stable than B.
The benzylpyrazolyl coumarin derivatives 5e and 6f exhibited the most cytotoxic effect on the promising cytotoxic activity with IC50 values 4.45 μg/mL against MDA-MB-231 and 4.85 μg/mL against MCF7, respectively.
American Psychological Association (APA)
Jelali, Hamida& Mtibaa, Ahlem Chakchouk& Baklouti, Lasaad& Bilel, Hallouma& Bathich, Yaser& Mellouli, L.…[et al.]. 2019. Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1171907
Modern Language Association (MLA)
Jelali, Hamida…[et al.]. Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins. Journal of Chemistry No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1171907
American Medical Association (AMA)
Jelali, Hamida& Mtibaa, Ahlem Chakchouk& Baklouti, Lasaad& Bilel, Hallouma& Bathich, Yaser& Mellouli, L.…[et al.]. Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1171907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171907