![](/images/graphics-bg.png)
Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy
Joint Authors
Karst, Sonja G.
Lammer, Jan
Radwan, Salma H.
Kwak, Hanna
Silva, Paolo S.
Burns, Stephen A.
Aiello, Lloyd Paul
Sun, Jennifer K.
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques.
Methods.
Cross-sectional study including 35 eyes of 34 study participants.
AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR.
Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images.
Main Outcome Measures.
Individual lesion characterization by AOSLO imaging.
AOSLO appearance was compared with CF and SDOCT imaging.
Results.
Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts.
AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT.
Conclusions.
AOSLO imaging provides detailed, noninvasive in vivo visualization of DR lesions enhancing the assessment of morphological characteristics.
These unique AOSLO attributes may enable new insights into the pathological changes of DR in response to disease onset, development, regression, and response to therapy.
American Psychological Association (APA)
Karst, Sonja G.& Lammer, Jan& Radwan, Salma H.& Kwak, Hanna& Silva, Paolo S.& Burns, Stephen A.…[et al.]. 2018. Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1171929
Modern Language Association (MLA)
Karst, Sonja G.…[et al.]. Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. International Journal of Endocrinology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1171929
American Medical Association (AMA)
Karst, Sonja G.& Lammer, Jan& Radwan, Salma H.& Kwak, Hanna& Silva, Paolo S.& Burns, Stephen A.…[et al.]. Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1171929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171929