The Role of Uron and Chlorobenzene Derivatives, as Potential Endocrine Disrupting Compounds, in the Secretion of ACTH and PRL
Joint Authors
Sepp, Krisztián
Molnár, Zsolt
László, Anna M.
Alapi, Tünde
Serester, Andrea
Valkusz, Zsuzsanna
Gálfi, Márta
Radács, Marianna
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Uron herbicides polluting the environment represent a serious concern for environmental health and may be regarded as endocrine-disrupting compounds (EDCs), which influence the regulation of human homeostasis.
We aimed to investigate the effect of EDC urons (phenuron: PU, monuron: MU, and diuron: DU) and chlorobenzenes on the basal release of the adrenocorticotropic hormone (ACTH), which is a part of the adenohypophysis-adrenocortical axis.
Hormone secretion in the presence of EDC was studied in two cell types: normal adenohypophysis cells (AdH) and cells of prolactinomas (PRLOMA).
PRLOMA was induced in female Wistar rats by subcutaneously injecting them with estrone acetate for 6 months.
AdH and PRLOMA were separated from treated and untreated experimental animals, dissociated enzymatically and mechanically in order to create monolayer cell cultures, which served as an experimental in vitro model.
We investigated the effects of ED agents separately and in combination on ACTH and prolactin (PRL) release through the hypophyseal-adrenal axis.
Hormone determination was carried out by the luminescent immunoassay and the radioimmunoassay methods.
Our results showed that (1) uron agents separately did not change ACTH and PRL release in AdH culture; (2) ACTH secretion in arginine vasopressin- (AVP-) activated AdH cells was significantly increased by EDC treatment; (3) ED agents increased the basal hormone release (ACTH, PRL) in PRLOMA cells; and (4) EDC exposure increased ACTH release in AVP-activated PRLOMA cells.
We conclude that the herbicides PU, MU, and DU carry EDC effects and show human toxicity potential.
American Psychological Association (APA)
Sepp, Krisztián& László, Anna M.& Molnár, Zsolt& Serester, Andrea& Alapi, Tünde& Gálfi, Márta…[et al.]. 2018. The Role of Uron and Chlorobenzene Derivatives, as Potential Endocrine Disrupting Compounds, in the Secretion of ACTH and PRL. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171962
Modern Language Association (MLA)
Sepp, Krisztián…[et al.]. The Role of Uron and Chlorobenzene Derivatives, as Potential Endocrine Disrupting Compounds, in the Secretion of ACTH and PRL. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171962
American Medical Association (AMA)
Sepp, Krisztián& László, Anna M.& Molnár, Zsolt& Serester, Andrea& Alapi, Tünde& Gálfi, Márta…[et al.]. The Role of Uron and Chlorobenzene Derivatives, as Potential Endocrine Disrupting Compounds, in the Secretion of ACTH and PRL. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171962