Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes
Joint Authors
Baik, Sei Hyun
Hwang, Soon Young
Chung, Hye Soo
Choi, Ju Hee
Lee, Hyun Jung
Yoo, Hye Jin
Kim, Sin Gon
Kim, Nan Hee
Choi, Kyung Mook
Seo, Ji A.
Choi, Dong Seop
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients.
Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.
Methods.
We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study.
Results.
Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels.
Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs.
599.5 [502.0, 709.3], P=0.001) and subjects with obesity (704.1 [595.5-880.9] vs.
612.2 [547.9-802.1], P=0.016).
In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals.
Multiple logistic regression analysis revealed that both individuals without obesity (P for trend = 0.017) and with obesity (P for trend = 0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile.
Conclusions.
This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.
American Psychological Association (APA)
Chung, Hye Soo& Lee, Hyun Jung& Hwang, Soon Young& Choi, Ju Hee& Yoo, Hye Jin& Seo, Ji A.…[et al.]. 2018. Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172071
Modern Language Association (MLA)
Chung, Hye Soo…[et al.]. Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1172071
American Medical Association (AMA)
Chung, Hye Soo& Lee, Hyun Jung& Hwang, Soon Young& Choi, Ju Hee& Yoo, Hye Jin& Seo, Ji A.…[et al.]. Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172071