A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Abstract EN

Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach.

The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction.

The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR spectrascopic data.

This finding was further concluded by X-ray crystal analysis.

The biological properties of these ligands were screened using the disc diffusion method.

The result shows that HLb shows significant inhibition towards all of the bacteria tested.