Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition
Joint Authors
Ivanova, G.
Chochkova, Maya G.
Petrova, Petranka P.
Stoykova, Boyka M.
Štícha, Martin
Dibó, Gábor
Milkova, Tsenka S.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Currently, there is an increasing interest towards α-glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B- and C-type viral hepatitis.
Cinnamic acid derivatives have been shown to be potentially valuable as a new group of α-glucosidase inhibitors.
Therefore, herein, the α-glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro.
Results revealed that the tested hydroxycinnamoyl amides (1–16) inhibited a-glucosidase with IC50s ranging between 0.76 and 355.1 μg/ml.
Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast α-glucosidase, being even more potent ones than the used positive inhibitor acarbose (IC50=2.50±0.21 μg/ml).
American Psychological Association (APA)
Chochkova, Maya G.& Petrova, Petranka P.& Stoykova, Boyka M.& Ivanova, G.& Štícha, Martin& Dibó, Gábor…[et al.]. 2017. Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1172104
Modern Language Association (MLA)
Chochkova, Maya G.…[et al.]. Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition. Journal of Chemistry No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1172104
American Medical Association (AMA)
Chochkova, Maya G.& Petrova, Petranka P.& Stoykova, Boyka M.& Ivanova, G.& Štícha, Martin& Dibó, Gábor…[et al.]. Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1172104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172104