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Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors
Joint Authors
Lania, Andrea Gerardo
Campana, Davide
Di Giacinto, Paola
Rota, Francesca
Rizza, Laura
Zuppi, Paolo
Baldelli, Roberto
Lenzi, Andrea
Isidori, Andrea Maria
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index.
The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate.
The PROMID trial assesses the effect of octreotide LAR on the tumor growth in patients with well-differentiated metastatic midgut NETs.
The CLARINET trial evaluates the effects of lanreotide in patients with nonfunctional, well-, or moderately differentiated metastatic enteropancreatic NETs.
Everolimus has been approved for the treatment of advanced pancreatic NETs (pNETs) based on positive PFS effects, obtained in the treated group.
Sunitinib is approved for the treatment of patients with progressive gastrointestinal stromal tumor or intolerance to imatinib, because a randomized study demonstrated that it improves PFS and overall survival in patients with advanced well-differentiated pNETs.
In a phase II trial, pasireotide shows efficacy and tolerability in the treatment of patients with advanced NETs, whose symptoms of carcinoid syndrome were resistant to octreotide LAR.
An open-label, phase II trial assesses the clinical activity of long-acting repeatable pasireotide in treatment-naive patients with metastatic grade 1 or 2 NETs.
Even if the growth of the neoplasm was significantly inhibited, it is still unclear whether its antiproliferative action is greater than that of octreotide and lanreotide.
Because new therapeutic options are needed to counter the natural behavior of neuroendocrine tumors, it would also be useful to have a biochemical marker that can be addressed better in the management of these patients.
Chromogranin A is currently the most useful biomarker to establish diagnosis and has some utility in predicting disease recurrence, outcome, and efficacy of therapy.
American Psychological Association (APA)
Di Giacinto, Paola& Rota, Francesca& Rizza, Laura& Campana, Davide& Isidori, Andrea Maria& Lania, Andrea Gerardo…[et al.]. 2018. Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172111
Modern Language Association (MLA)
Di Giacinto, Paola…[et al.]. Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors. International Journal of Endocrinology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1172111
American Medical Association (AMA)
Di Giacinto, Paola& Rota, Francesca& Rizza, Laura& Campana, Davide& Isidori, Andrea Maria& Lania, Andrea Gerardo…[et al.]. Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172111