A Novel Green Synthesis of Thalidomide and Analogs
Joint Authors
Benjamin, Ellis
Hijji, Yousef M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties.
Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures.
Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system.
The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.
American Psychological Association (APA)
Benjamin, Ellis& Hijji, Yousef M.. 2017. A Novel Green Synthesis of Thalidomide and Analogs. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1172180
Modern Language Association (MLA)
Benjamin, Ellis& Hijji, Yousef M.. A Novel Green Synthesis of Thalidomide and Analogs. Journal of Chemistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1172180
American Medical Association (AMA)
Benjamin, Ellis& Hijji, Yousef M.. A Novel Green Synthesis of Thalidomide and Analogs. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1172180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172180