Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review
Joint Authors
Sirisena, Nirmala D.
Prabodha, L. B. L.
Dissanayake, Vajira H. W.
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism.
It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level.
Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients.
It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations.
The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative stress and altered polyol metabolism that changes the nerve microvasculature, altered growth factor support, and deregulated lipid metabolism.
Recent literature has reported that there are several heterogeneous groups of susceptible genetic loci which clearly contribute to the development of DPN.
Several studies have reported that some patients with prediabetes develop neuropathic complications, whereas others demonstrated little evidence of neuropathy even after long-standing diabetes.
There is emerging evidence that genetic factors may contribute to the development of DPN.
This paper aims to provide an up-to-date review of the susceptible and prognostic genetic factors associated with DPN.
An extensive survey of the scientific literature published in PubMed using the search terms “Diabetic peripheral neuropathy/genetics” and “genome-wide association study” was carried out, and the most recent and relevant literature were included in this review.
American Psychological Association (APA)
Prabodha, L. B. L.& Sirisena, Nirmala D.& Dissanayake, Vajira H. W.. 2018. Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172208
Modern Language Association (MLA)
Prabodha, L. B. L.…[et al.]. Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1172208
American Medical Association (AMA)
Prabodha, L. B. L.& Sirisena, Nirmala D.& Dissanayake, Vajira H. W.. Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172208