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The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement
Joint Authors
Chen, Xuedi
Gao, Cuixia
Gong, Ningning
Wang, Yu
Tian, Limin
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
The main purpose of this study was to explore the relationships between serca2a, Ryr2, adipokines, and the left ventricular function in the subclinical hypothyroidism with different TSH levels and to determine the impact of L-T4 treatment on these indexes.
Methods.
Sixty-five male Wistar rats were randomly divided into five groups: control group; sHT A, B, and C group; and sHT + T4 group.
The sHT rats were induced by methimazole (MMI), and the sHT + T4 rats were administered with L-T4 treatment after 8 weeks of MMI administration.
Serum TT4, TSH, APN, chemerin, and TNF-α were detected by radioimmunoassay kits and ELISA kits; left ventricular function was measured by PowerLab system via subclavian artery catheter.
The expression of Serca2a, Ryr2, APN, chemerin, and TNF-α were detected by RT-PCR, Western blot, and immunohistochemistry.
Results.
The sHT groups had significantly higher TSH, chemerin, and TNF-α and lower Serca2a, Ryr2, and APN.
The left ventricular pressure and heart rate in sHT groups were significantly lower in control and sHT + T4 group.
Histopathological examination revealed the pathological changes in the sHT rats’ heart.
L-T4 administration reduced TSH level and improved left ventricular function.
Conclusions.
TSH can impair left ventricular function by regulating several factors, and L-T4 treatment ameliorates it in sHT rats.
American Psychological Association (APA)
Chen, Xuedi& Gao, Cuixia& Gong, Ningning& Wang, Yu& Tian, Limin. 2018. The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172219
Modern Language Association (MLA)
Chen, Xuedi…[et al.]. The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172219
American Medical Association (AMA)
Chen, Xuedi& Gao, Cuixia& Gong, Ningning& Wang, Yu& Tian, Limin. The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172219