Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials
Joint Authors
Liu, Wei
Yang, Xiao-Jie
Huang, Jing
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Insulin degludec (IDeg) and insulin glargine (IGlar) are both proved to be effective in diabetes.
This study aimed to assess the effects and safety of IDeg versus IGlar.
Methods.
A systematic literature search was conducted using the PubMed, EMBASE, and Cochrane Library electronic databases to identify all randomized controlled trials (RCTs).
Results.
Fifteen RCTs were identified.
The combined data showed that the decrease in the glycosylated hemoglobin (HbA1c) level was slightly different, and the proportion of patients who achieved HbA1c < 7% was similar between the IDeg and IGlar groups.
Further, a statistically significant decrease in the fasting plasma glucose level was observed in the IDeg group as compared to the IGlar group.
In patients with T2DM, IDeg was associated with lower rates of overall hypoglycemia.
Nocturnal hypoglycemia was significantly lower in the case of IDeg than in the case of IGlar in both T1DM and T2DM patients.
No statistically significant differences were observed between the groups.
Conclusions.
Compared with IGlar, IDeg is associated with equivalent glycemic control and a statistically significantly lower rate of nocturnal hypoglycemia in patients with T1DM and T2DM.
In T2DM patients, IDeg also provides better results in terms of overall hypoglycemia.
American Psychological Association (APA)
Liu, Wei& Yang, Xiao-Jie& Huang, Jing. 2018. Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172235
Modern Language Association (MLA)
Liu, Wei…[et al.]. Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172235
American Medical Association (AMA)
Liu, Wei& Yang, Xiao-Jie& Huang, Jing. Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172235