Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation
Joint Authors
Karim, Abdul
Ashraf Shaheen, Muhammad
Mehmood, Tahir
Raza, Abdul Rauf
Aziz, Musadiq
Din, Badar
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS).
A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32 factorial designs.
The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism.
A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time.
The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed.
The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability.
The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.
American Psychological Association (APA)
Karim, Abdul& Ashraf Shaheen, Muhammad& Mehmood, Tahir& Raza, Abdul Rauf& Aziz, Musadiq& Din, Badar. 2017. Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1172266
Modern Language Association (MLA)
Karim, Abdul…[et al.]. Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation. Journal of Chemistry No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1172266
American Medical Association (AMA)
Karim, Abdul& Ashraf Shaheen, Muhammad& Mehmood, Tahir& Raza, Abdul Rauf& Aziz, Musadiq& Din, Badar. Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1172266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172266