Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials
Joint Authors
Yaqub, Ghazala
Hamid, Almas
Fatima, Amber
Ijaz, Zainab
Sadiq, Zubi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Work presented herein is the first report of two dual-action hybrids synthesized by covalent linkage of carbazole based novel antibacterial compounds with efflux pump inhibitors, that is, indole acetic acid/gallic acid.
In this paper, novel antibacterial compounds 2 and 3 were prepared first and then these were covalently linked with efflux pump inhibitors, that is, indole acetic acid/gallic acid leading to the successful formation of two dual-action hybrids 4 and 5.
Prepared antibacterials and hybrids were evaluated for their bacteria cell killing capability against Escherichia coli, Staphylococcus aureus, Pasteurella multocida, and Bacillus subtilis.
Both antibacterial compounds 2 and 3 were found effective against all tested bacterial strains at different concentrations.
But when these compounds were linked with efflux pump inhibitors, they showed dramatic enhancement in their bacterial cell killing potential and minimum inhibitory concentration of all hybrids ranging from 7.250 μg/mL to 0.05 μg/mL.
These prepared hybrid drugs will be promising and effective new agents in the category of dual-action antibiotics.
American Psychological Association (APA)
Yaqub, Ghazala& Sadiq, Zubi& Hamid, Almas& Fatima, Amber& Ijaz, Zainab. 2017. Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1172306
Modern Language Association (MLA)
Yaqub, Ghazala…[et al.]. Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials. Journal of Chemistry No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1172306
American Medical Association (AMA)
Yaqub, Ghazala& Sadiq, Zubi& Hamid, Almas& Fatima, Amber& Ijaz, Zainab. Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1172306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172306