Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy
Joint Authors
Schlaich, Markus P.
Matthews, V. B.
Herat, Lakshini Y.
Rakoczy, P. Elizabeth
Carnagarin, Revathy
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prevalence of diabetes is at pandemic levels in today’s society.
Microvascular complications in organs including the eye are commonly observed in human diabetic subjects.
Diabetic retinopathy (DR) is a prominent microvascular complication observed in many diabetics and is particularly debilitating as it may result in impaired or complete vision loss.
In addition, DR is extremely costly for the patient and financially impacts the economy as a range of drug-related therapies and laser treatment may be essential.
Prevention of microvascular complications is the major treatment goal of current therapeutic approaches; however, these therapies appear insufficient.
Presently, sodium glucose cotransporter-2 (SGLT2) inhibitors may offer a novel therapy beyond simple glucose lowering.
Excitingly, the EMPA-REG clinical trial, which focuses on the clinically used SGLT2 inhibitor empagliflozin, has been extremely fruitful and has highlighted beneficial cardiovascular and renal outcomes.
The effects of SGLT2 inhibitors on DR are currently a topic of much research as outlined in the current review, but future studies are urgently needed to fully gain mechanistic insights.
Here, we summarize current evidence and identify gaps that need to be addressed.
American Psychological Association (APA)
Herat, Lakshini Y.& Matthews, V. B.& Rakoczy, P. Elizabeth& Carnagarin, Revathy& Schlaich, Markus P.. 2018. Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172314
Modern Language Association (MLA)
Herat, Lakshini Y.…[et al.]. Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1172314
American Medical Association (AMA)
Herat, Lakshini Y.& Matthews, V. B.& Rakoczy, P. Elizabeth& Carnagarin, Revathy& Schlaich, Markus P.. Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172314