Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders
Author
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Accumulating data from various clinical trial studies suggests that adjuvant therapy with ovarian hormones (estrogens) could be effective in reducing cognitive deficit and psychopathological symptoms in women with psychiatric disorders.
However, estrogen therapy poses serious limitations and health issues including feminization in men and increased risks of thromboembolism, hot flashes, breast hyperplasia, and endometrium hyperplasia when used for longer duration in older women (aged ≥ 60 years) or in women who have genetic predispositions.
On the other hand, selective estrogen receptor modulators (SERMs), which may (or may not) carry some risks of hot flashes, thromboembolism, breast hyperplasia, and endometrial hyperplasia, are generally devoid of feminization effect.
In clinical trial studies, adjuvant therapy with tamoxifen, a triphenylethylene class of SERM, has been found to reduce the frequency of manic episodes in patients with bipolar disorder, whereas addition of raloxifene, a benzothiophene class of SERM, to regular doses of antipsychotic drugs has been found to reduce cognitive deficit and psychological symptoms in men and women with schizophrenia, including women with treatment refractory psychosis.
These outcomes together with potent neurocognitive, neuroprotective, and cardiometabolic properties suggest that SERMs could be the potential targets for designing effective and safer therapies for psychiatric disorders.
American Psychological Association (APA)
Khan, Mohammad M.. 2018. Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172345
Modern Language Association (MLA)
Khan, Mohammad M.. Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders. International Journal of Endocrinology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1172345
American Medical Association (AMA)
Khan, Mohammad M.. Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172345