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Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants
Joint Authors
Takiff, H.
Aranaga, C. A.
Fraile, S.
Falco, A.
Michelangeli, F.
Torres, A.
Source
International Journal of Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Global control and elimination of tuberculosis are hindered by the high prevalence of drug-resistant strains, making the development of new drugs to fight tuberculosis a public health priority.
In this study, we evaluated 118 extracts from 58 Venezuelan plant species for their ability to inhibit the growth of Mycobacterium tuberculosis mc26020, using the agar dilution method.
Additionally, we determined the ability of these extracts to inhibit the activity of PknB protein, an essential M.
tuberculosis serine/threonine kinase, using a high-throughput luminescent assay.
Of the 118 extracts tested, 14 inhibited bacterial growth with a minimum inhibitory concentration ≤500 μg/ml, and 36 inhibited the kinase activity with a half-maximal inhibitory concentration <200 μg/ml.
Five extracts inhibited M.
tuberculosis growth and inhibited the activity of the kinase protein, suggesting that this could be the basis of their growth inhibition.
American Psychological Association (APA)
Aranaga, C. A.& Fraile, S.& Torres, A.& Falco, A.& Michelangeli, F.& Takiff, H.. 2020. Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants. International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172353
Modern Language Association (MLA)
Aranaga, C. A.…[et al.]. Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants. International Journal of Microbiology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1172353
American Medical Association (AMA)
Aranaga, C. A.& Fraile, S.& Torres, A.& Falco, A.& Michelangeli, F.& Takiff, H.. Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants. International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172353