Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study
Joint Authors
Mráz, Miloš
Jiskra, Jan
Krátký, Jan
Vítková, Hana
Ježková, Jana
Kosák, Mikuláš
Bartáková, Jana
Lukáš, Jindřich
Límanová, Zdenka
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The relationship between Hashimoto’s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC.
The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules.
We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule.
Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included.
Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs.
27% in controls, P=0.005, anti-TG 35% in TC group vs.
21% in controls, P=0.018), and the TC group had significantly higher TSH (median 1.88 mIU/l vs.
1.21 mIU/l, P<0.001).
Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, P=0.018), while spontaneously suppressed TSH<0.5 mIU/l was a protective factor (OR 0.3, P=0.01) against TC.
In conclusion, nodules in subjects with positive antithyroid antibodies could be considered to have a higher risk of malignancy.
However, based on our results, it is not possible to declare that TC is triggered by HT.
American Psychological Association (APA)
Krátký, Jan& Ježková, Jana& Kosák, Mikuláš& Vítková, Hana& Bartáková, Jana& Mráz, Miloš…[et al.]. 2018. Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172372
Modern Language Association (MLA)
Krátký, Jan…[et al.]. Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study. International Journal of Endocrinology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1172372
American Medical Association (AMA)
Krátký, Jan& Ježková, Jana& Kosák, Mikuláš& Vítková, Hana& Bartáková, Jana& Mráz, Miloš…[et al.]. Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172372