Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine
Joint Authors
Wan Aasim, Wan Raihana
Tan, Soo Choon
Gan, Siew Hua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide.
To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding.
The stereoselective protein binding of rac-MDMA was investigated using two different concentrations (20 and 200 ng/mL) in human plasma and mouse and rat sera using an ultrafiltration technique.
No significant stereoselectivity in protein binding was observed in both human plasma and rat serum; however, a significant stereoselective binding (p<0.05) was observed in mouse serum.
Since the protein binding of MDMA in mouse serum is considerably lower than in humans and rats, caution should be exercised when using mice for in vitro studies involving MDMA.
American Psychological Association (APA)
Wan Aasim, Wan Raihana& Tan, Soo Choon& Gan, Siew Hua. 2017. Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172378
Modern Language Association (MLA)
Wan Aasim, Wan Raihana…[et al.]. Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine. Journal of Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1172378
American Medical Association (AMA)
Wan Aasim, Wan Raihana& Tan, Soo Choon& Gan, Siew Hua. Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172378