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Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease
Joint Authors
Park, Do Joon
Park, Young Joo
Kim, Min Joo
Cho, Sun Wook
Choi, Sumin
Ju, Dal Lae
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves’ disease.
Methods.
A prospective cohort study was performed with six women newly diagnosed with Graves’ disease.
During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively.
Results.
After methimazole treatment, body weight was initially increased (0–8 weeks), subsequently plateaued (8–24 weeks), and gradually decreased in the later period (24–52 weeks) despite the decreased food intake.
The measured REE was 40% higher than the predicted REE at baseline, and it gradually decreased after treatment.
REE positively correlated with thyroid hormone levels, peripheral deiodinase activity, and thyroid’s secretory capacity.
Body compositional analyses showed that the fat mass increased during an earlier period (4–12 weeks), while the lean mass increased significantly during the later period (26–52 weeks).
Consistent with the lean mass changes, muscle strength also significantly increased during the later period.
Conclusions.
Treatment of Graves’ disease increased body weight and fat mass transiently with decreased REE.
However, long-term compositional changes moved in a beneficial direction increasing lean mass and reinforcing muscle strength, following decreasing fat percentages.
American Psychological Association (APA)
Kim, Min Joo& Cho, Sun Wook& Choi, Sumin& Ju, Dal Lae& Park, Do Joon& Park, Young Joo. 2018. Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172386
Modern Language Association (MLA)
Kim, Min Joo…[et al.]. Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1172386
American Medical Association (AMA)
Kim, Min Joo& Cho, Sun Wook& Choi, Sumin& Ju, Dal Lae& Park, Do Joon& Park, Young Joo. Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172386