Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives
Joint Authors
Pivazyan, Vergush A.
Ghazaryan, Emma A.
Shainova, Roza S.
Tamazyan, Rafael A.
Ayvazyan, Armen G.
Yengoyan, Aleksandr P.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A convenient, accessible, and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1) by treatment of acetoacetic acid ethyl ester with thiourea in sodium methylate was developed.
The alkylation of the latter with 3-chloro-pentane-2,4-dione and further regioselective cyclization of intermediate compound (2) in high yield afforded 2-acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one (3).
The halogenation and some transformations of synthesized thiazolo[3,2-a]pyrimidine (3) due to its ketone group were carried out to obtain the corresponding carboxamide, carbothioamide, sulfonohydrazide, and oxime and its alkylated derivatives (5).
At preliminary biological studies the synthesized compounds have shown growth stimulant properties.
The activity of four of them was higher than 70%, compared with heteroauxin.
American Psychological Association (APA)
Pivazyan, Vergush A.& Ghazaryan, Emma A.& Shainova, Roza S.& Tamazyan, Rafael A.& Ayvazyan, Armen G.& Yengoyan, Aleksandr P.. 2017. Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172407
Modern Language Association (MLA)
Pivazyan, Vergush A.…[et al.]. Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives. Journal of Chemistry No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1172407
American Medical Association (AMA)
Pivazyan, Vergush A.& Ghazaryan, Emma A.& Shainova, Roza S.& Tamazyan, Rafael A.& Ayvazyan, Armen G.& Yengoyan, Aleksandr P.. Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172407