Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation
Joint Authors
Treuer, Adriana V.
De-La-Torre, Pedro
Gutiérrez, Margarita
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Given the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives, it is necessary to find simple methods to synthesize and diversify this family of compounds.
We report a stereoselective synthesis of a series of new (E)-2-(1H-indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles (3a–3i) obtained from 3-(cyanoacetyl)indole and heteroaryl-aldehydes under microwave-assisted Knoevenagel reaction at 300 W of potency and 100°C.
The desired derivatives (3a–3i) were obtained with variable yields (30–94%) and time reactions (8–90 min).
All the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such IR, 1H, 13C NMR, and electrospray mass spectrometry.
American Psychological Association (APA)
Treuer, Adriana V.& De-La-Torre, Pedro& Gutiérrez, Margarita. 2017. Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172428
Modern Language Association (MLA)
Treuer, Adriana V.…[et al.]. Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation. Journal of Chemistry No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1172428
American Medical Association (AMA)
Treuer, Adriana V.& De-La-Torre, Pedro& Gutiérrez, Margarita. Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172428