A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography
Joint Authors
Plotycya, Serhij
Strontsitska, Oksana
Blazheyevskiy, Mykola
Pysarevska, Solomiya
Dubenska, Liliya
Source
International Journal of Electrochemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed.
Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored.
It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1.
The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively.
In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed.
The results of the analysis are in good agreement with the product specifications described in the quality certificates.
The possibility of quantitative determination of benzocaine and procaine in pharmaceuticals is confirmed.
American Psychological Association (APA)
Plotycya, Serhij& Strontsitska, Oksana& Pysarevska, Solomiya& Blazheyevskiy, Mykola& Dubenska, Liliya. 2018. A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography. International Journal of Electrochemistry،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172455
Modern Language Association (MLA)
Plotycya, Serhij…[et al.]. A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography. International Journal of Electrochemistry No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172455
American Medical Association (AMA)
Plotycya, Serhij& Strontsitska, Oksana& Pysarevska, Solomiya& Blazheyevskiy, Mykola& Dubenska, Liliya. A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography. International Journal of Electrochemistry. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172455