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Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents
Joint Authors
Cruz, Inês
Puthongking, Ploenthip
Cravo, Sara
Palmeira, Andreia
Cidade, Honorina
Pinto, Madalena
Sousa, Emília
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that is associated with the elderly.
The current therapy that is used to treat AD is based mainly on the administration of acetylcholinesterase (AChE) inhibitors.
Due to their low efficacy there is a considerable need for other therapeutic strategies.
Considering that the malfunctions of different, but interconnected, biochemical complex pathways play an important role in the pathogenesis of this disease, a promising therapy may consist in administration of drugs that act on more than a target on biochemical scenery of AD.
In this work, the synthesis and evaluation of xanthone and flavone derivatives as antioxidants with AChE inhibitory activity were accomplished.
Among the obtained compounds, Mannich bases 3 and 14 showed capacity to inhibit AChE and antioxidant property, exerting dual activity.
Moreover, for the most promising AChE inhibitors, docking studies on the target have been performed aiming to predict the binding mechanism.
The results presented here may help to identify new xanthone and flavone derivatives as dual anti-Alzheimer agents with AChE inhibitory and antioxidant activities.
American Psychological Association (APA)
Cruz, Inês& Puthongking, Ploenthip& Cravo, Sara& Palmeira, Andreia& Cidade, Honorina& Pinto, Madalena…[et al.]. 2017. Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1172464
Modern Language Association (MLA)
Cruz, Inês…[et al.]. Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents. Journal of Chemistry No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1172464
American Medical Association (AMA)
Cruz, Inês& Puthongking, Ploenthip& Cravo, Sara& Palmeira, Andreia& Cidade, Honorina& Pinto, Madalena…[et al.]. Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1172464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172464