Electrochemical Analysis of Ultrathin Polythiolsiloxane Films for Surface Biomodification
Joint Authors
Chiang, Hao-Chun
Levicky, Rastislav
Source
International Journal of Electrochemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The ability of different crosslinkers to crosslink nanometer thick films of the polymer poly(mercaptopropyl)methylsiloxane (PMPMS), thus stabilizing these films on solid supports, was investigated.
The four crosslinkers included 1,11-bismaleimidotriethyleneglycol (BM(PEG)3), tris-(2-maleimidoethyl)amine (TMEA), bismaleimidohexane (BMH), and 1,1′-(methylenedi-4,1-phenylene) bismaleimide (BMDPM).
PMPMS films treated with the four crosslinkers were compared in the effectiveness of achieved crosslinking, continuity and stability of the films to rearrangement at elevated temperatures, and modification with single-stranded DNA.
The results of electrochemical analyses show that more hydrophilic crosslinkers had difficulty reacting fully with PMPMS thiols, even in these nanometer thin layers.
This observation highlights the critical importance of selecting crosslinkers that are chemically compatible.
Optimal selection of crosslinker yielded films in which the polymer film was largely incapable of rearranging, even at elevated temperatures, yielding reproducible and stable layers.
These results validate use of these supports for applications such as monitoring thermal denaturation of immobilized DNA duplexes.
American Psychological Association (APA)
Chiang, Hao-Chun& Levicky, Rastislav. 2018. Electrochemical Analysis of Ultrathin Polythiolsiloxane Films for Surface Biomodification. International Journal of Electrochemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172478
Modern Language Association (MLA)
Chiang, Hao-Chun& Levicky, Rastislav. Electrochemical Analysis of Ultrathin Polythiolsiloxane Films for Surface Biomodification. International Journal of Electrochemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1172478
American Medical Association (AMA)
Chiang, Hao-Chun& Levicky, Rastislav. Electrochemical Analysis of Ultrathin Polythiolsiloxane Films for Surface Biomodification. International Journal of Electrochemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172478