Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis
Joint Authors
Derseh, Lemma
Gelaw, Baye
Kindu, Mizan
Moges, Feleke
Source
International Journal of Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-04
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Background.
Studies have reported that the existence of CP bacteria in Africa, but, in general, comprehensive data about the molecular epidemiology of CP organisms are limited.
Therefore, this systematic review and meta-analysis expound the pooled prevalence of CP P.
aeruginosa and CP A.
baumannii clinical isolates in Africa.
It also identified the diversity of carbapenemases or their encoding genes among the isolates in Africa.
Lastly, the review observed the trends of these CP isolates in Africa.
Methods.
A comprehensive search was performed between July 2019 and October 2019 in the following databases: PubMed, Google Scholar, and African Journal online.
The included articles were published only in English.
The screening was done by two authors independently.
The data extracted on Excel spreadsheet were transferred to STATA 11 software for analysis.
Results.
From a total of 1,454 articles searched, 42 articles were eligible.
Most of the studies were conducted in the North Africa region.
But there was no report from Central Africa.
The pooled prevalence of CP P.
aeruginosa and CP A.
baumannii among the clinical specimens in Africa was 21.36% and 56.97%, respectively.
OXA-23 and VIM were the most prevailing carbapenemase among P.
aeruginosa and A.
baumannii, respectively.
The cumulative meta-analysis revealed a relative increment of the prevalence of CP P.
aeruginosa over time in Africa but it showed a higher prevalence of CP A.
baumannii isolates across years.
Conclusion.
The review revealed a high pooled prevalence of CP A.
baumannii clinical isolates in Africa which needs urgent action.
Moreover, the emergence of concomitant carbapenemases, especially OXA-23 + NDM among CP A.
baumannii, was also an alarming problem.
American Psychological Association (APA)
Kindu, Mizan& Derseh, Lemma& Gelaw, Baye& Moges, Feleke. 2020. Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis. International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1172556
Modern Language Association (MLA)
Kindu, Mizan…[et al.]. Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis. International Journal of Microbiology No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1172556
American Medical Association (AMA)
Kindu, Mizan& Derseh, Lemma& Gelaw, Baye& Moges, Feleke. Carbapenemase-Producing Non-Glucose-Fermenting Gram-Negative Bacilli in Africa, Pseudomonas aeruginosa and Acinetobacter baumannii: A Systematic Review and Meta-Analysis. International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1172556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172556