Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231
Joint Authors
Salerno, Loredana
Modica, Maria N.
Pittalà, Valeria
Barresi, Vincenza
Bonaccorso, Carmela
Cristaldi, Domenico A.
Musso, Nicolò
Fortuna, Cosimo G.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents.
With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors.
Based on the obtained results, we constructed a Volsurf+ (VS+) model using a dataset of 59 compounds able to predict the in vitro antitumor activity against MCF-7 cancer cell line for new derivatives.
In the present paper, in order to further verify the robustness of this model, we report the results of the projection of more than 150 known molecules and 9 newly synthesized compounds.
We predict their activity versus MCF-7 cell line and experimentally verify the in silico results for some promising chosen molecules in two human breast cell lines, MCF-7 and MDA-MB-231.
American Psychological Association (APA)
Barresi, Vincenza& Bonaccorso, Carmela& Cristaldi, Domenico A.& Modica, Maria N.& Musso, Nicolò& Pittalà, Valeria…[et al.]. 2017. Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1172617
Modern Language Association (MLA)
Barresi, Vincenza…[et al.]. Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231. Journal of Chemistry No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1172617
American Medical Association (AMA)
Barresi, Vincenza& Bonaccorso, Carmela& Cristaldi, Domenico A.& Modica, Maria N.& Musso, Nicolò& Pittalà, Valeria…[et al.]. Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1172617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172617