Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes
Joint Authors
Yuan, Guangxin
Xu, Guangyu
Bai, Yu
Zhang, Yuhang
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tuberculosis (TB) is one of the deadliest infectious diseases worldwide.
In Mycobacterium tuberculosis, changes in gene expression are highly variable and involve many genes, so traditional single-gene screening of M.
tuberculosis targets has been unable to meet the needs of clinical diagnosis.
In this study, using the National Center for Biotechnology Information (NCBI) GEO Datasets, whole blood gene expression profile data were obtained in patients with active pulmonary tuberculosis.
Linear model-experience Bayesian statistics using the Limma package in R combined with t-tests were applied for nonspecific filtration of the expression profile data, and the differentially expressed human genes were determined.
Using DAVID and KEGG, the functional analysis of differentially expressed genes (GO analysis) and the analysis of signaling pathways were performed.
Based on the differentially expressed gene, the transcriptional regulatory element databases (TRED) were integrated to construct the M.
tuberculosis pathogenic gene regulatory network, and the correlation of the network genes with disease was analyzed with the DAVID online annotation tool.
It was predicted that IL-6, JUN, and TP53, along with transcription factors SRC, TNF, and MAPK14, could regulate the immune response, with their function being extracellular region activity and protein binding during infection with M.
tuberculosis.
American Psychological Association (APA)
Yuan, Guangxin& Bai, Yu& Zhang, Yuhang& Xu, Guangyu. 2018. Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172710
Modern Language Association (MLA)
Yuan, Guangxin…[et al.]. Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes. International Journal of Genomics No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1172710
American Medical Association (AMA)
Yuan, Guangxin& Bai, Yu& Zhang, Yuhang& Xu, Guangyu. Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1172710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172710