Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
Joint Authors
Mahmoudi, Reza
Nikseresht, Mohsen
Teshnizi, Saeed Hosseini
Dehghani, Mehdi
Samani, Zahra
Abidi, Hassan
Manzouri, Leila
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids.
These compounds can be effective in the growth and development of tumors.
One of the enzymes involved in the mevalonate pathway is FDFT1.
Different variants of this gene are involved in the risk of suffering various diseases.
The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran.
Method.
The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples: 34 patients with NSCLC and 61 healthy individuals by RFLP method.
Results.
The results of this study indicated that C allele of this polymorphism was effectively associated with the risk of NSCLC in the Iranian population (p value = 0.023; OR = 2.71; 95% CI = 1.12–6.59) and CC genotype has significant relation with susceptibility to NSCLC (p value = 0.029; OR = 3.02; 95% CI = 1.09–8.39).
This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter.
This study also found a significant relationship between C allele and metastatic status.
C allele was more common in NSCLC patients.
(p=0.04).
Conclusion.
C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role.
American Psychological Association (APA)
Dehghani, Mehdi& Samani, Zahra& Abidi, Hassan& Manzouri, Leila& Mahmoudi, Reza& Teshnizi, Saeed Hosseini…[et al.]. 2018. Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1172748
Modern Language Association (MLA)
Dehghani, Mehdi…[et al.]. Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer. International Journal of Genomics No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1172748
American Medical Association (AMA)
Dehghani, Mehdi& Samani, Zahra& Abidi, Hassan& Manzouri, Leila& Mahmoudi, Reza& Teshnizi, Saeed Hosseini…[et al.]. Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1172748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172748