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Cerebellar lncRNA Expression Profile Analysis of SCA3MJD Mice
Joint Authors
Tang, Bei-sha
Xia, Kun
Long, Zhe
Li, Tianjiao
Chen, Zhao
Peng, Yun
Wang, Chunrong
Hou, Xiaocan
Yuan, Hongyu
Wang, Puzhi
Xie, Yue
He, Lang
Zhou, Xin
Peng, Huirong
Qiu, Rong
Jiang, Hong
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) is the most common autosomal dominant spinocerebellar ataxia in China with highly clinical heterogeneity, such as progressive cerebellar ataxia, dysarthria, pyramidal signs, external ophthalmoplegia, dysphagia, and distal muscle atrophy.
It is caused by the abnormal expansion of CAG repeats in a coding region of ATXN3.
However, by focusing on the ATXN3 itself cannot fully explain the heterogeneous clinical features of SCA3/MJD.
With the discovery of the increasing number of long noncoding RNAs (lncRNAs) that are believed to be involved in spinocerebellar ataxia type 8 (SCA8) and Huntington disease (HD), we wonder whether the lncRNAs are differentially expressed in the SCA3/MJD patients compared to the nonpatients.
As the first step, we used lncRNA-Seq to investigate differential expression of the lncRNAs in the SCA3/MJD mice.
Two known lncRNAs, n297609 and n297477, and a novel lncRNA TCONS_00072962 have been identified in SCA3/MJD mice with abnormal expression.
The first discovery of the novel lncRNA TCONS_00072962 enriched the lncRNA expression profile in the SCA3/MJD mouse model.
American Psychological Association (APA)
Long, Zhe& Li, Tianjiao& Chen, Zhao& Peng, Yun& Wang, Chunrong& Hou, Xiaocan…[et al.]. 2018. Cerebellar lncRNA Expression Profile Analysis of SCA3MJD Mice. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172761
Modern Language Association (MLA)
Long, Zhe…[et al.]. Cerebellar lncRNA Expression Profile Analysis of SCA3MJD Mice. International Journal of Genomics No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1172761
American Medical Association (AMA)
Long, Zhe& Li, Tianjiao& Chen, Zhao& Peng, Yun& Wang, Chunrong& Hou, Xiaocan…[et al.]. Cerebellar lncRNA Expression Profile Analysis of SCA3MJD Mice. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1172761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172761