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The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics
Joint Authors
Krishnan, Preethi
Damaraju, Sambasivarao
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Discoveries on nonprotein-coding RNAs have induced a paradigm shift in our overall understanding of gene expression and regulation.
We now understand that coding and noncoding RNA machinery work in concert to maintain overall homeostasis.
Based on their length, noncoding RNAs are broadly classified into two groups—long (>200 nt) and small noncoding RNAs (<200 nt).
These RNAs perform diverse functions—gene regulation, splicing, translation, and posttranscriptional modifications.
MicroRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs) are two classes of small noncoding RNAs that are now classified as master regulators of gene expression.
They have also demonstrated clinical significance as potential biomarkers and therapeutic targets for several diseases, including cancer.
Despite these similarities, both these RNAs are generated through contrasting mechanisms, and one of the aims of this review is to cover the distance travelled since their discovery and compare and contrast the various facets of these RNAs.
Although these RNAs show tremendous promise as biomarkers, translating the findings from bench to bedside is often met with roadblocks.
The second aim of this review therefore is to highlight some of the challenges that hinder application of miRNA and piRNA as in guiding treatment decisions.
American Psychological Association (APA)
Krishnan, Preethi& Damaraju, Sambasivarao. 2018. The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1172785
Modern Language Association (MLA)
Krishnan, Preethi& Damaraju, Sambasivarao. The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics. International Journal of Genomics No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1172785
American Medical Association (AMA)
Krishnan, Preethi& Damaraju, Sambasivarao. The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1172785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172785