Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study
Joint Authors
Mwemezi, Oswin
Ruggajo, Paschal
Mngumi, Jonathan
Furia, Francis F
Source
International Journal of Nephrology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
HIV-associated renal dysfunction is common among infected patients; the growing burden of this condition may be partly accounted for by improved survival attributed to sustained viral suppression with antiretroviral therapies (ART).
Some ART regimens are nephrotoxic and may potentially contribute to renal dysfunction observed in these patients.
This study aimed at investigating the prevalence of renal dysfunction among people living with HIV (PLHIV) on ART attending the care and treatment clinic (CTC).
Methods.
A cross-sectional study was conducted between June and October 2019 among adults living with HIV on ART for 6 months or more attending CTC at Muhimbili National Hospital in Dar es Salaam, Tanzania.
A total of 287 participants were screened for proteinuria and microalbuminuria using the Cybow 300 urine analyzer.
Serum creatinine was tested for all participants, and it was used to estimate glomerular filtration rate (eGFR) using the CKD-EPI formula.
Results.
Out of 287 participants (72.1% female, mean age ± SD: 46.7 ± 10.6 years), about one-third (32.8%) had eGFR less than 90 ml/min, whereas 7% had eGFR less than 60 ml/min.
Microalbuminuria and proteinuria were detected in 38.6% and 25.1% of participants, respectively.
In the multivariate analysis, predictive determinants for renal dysfunction were higher viral loads (OR 2.5 (1.1–5.8), p=0.031), diabetes mellitus (OR 5.5 (1.6–18.6), p=0.006), and age above 60 years (OR 2.8 (1.0–7.3), p=0.041); however, this was not the case for serum CD4 counts (OR 1.25 (0.7–2.3), p=0.46).
Conclusion.
High prevalence of renal dysfunction among PLHIV on ART was noted in this study.
Viral loads above 1000 cp/ml and diabetes mellitus were noted to be associated with increased risk for renal dysfunction.
American Psychological Association (APA)
Mwemezi, Oswin& Ruggajo, Paschal& Mngumi, Jonathan& Furia, Francis F. 2020. Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1172800
Modern Language Association (MLA)
Mwemezi, Oswin…[et al.]. Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study. International Journal of Nephrology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1172800
American Medical Association (AMA)
Mwemezi, Oswin& Ruggajo, Paschal& Mngumi, Jonathan& Furia, Francis F. Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1172800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172800