Discovery of Novel Caeridins from the Skin Secretion of the Australian White’s Tree Frog, Litoria caerulea
Joint Authors
Zhou, Mei
Wang, Lei
Xi, Xinping
Li, Lei
Wu, Qing
Wang, Xi
Lu, Huimin
Watson, Chris J.
Chen, Tianbao
Source
International Journal of Genomics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Abundant biologically active peptides have been discovered from frog skin secretions, a rich natural source of bioactive compounds with great potential in drug discovery.
In this study, three Caeridin peptides, namely, Caeridin-1, S5-Caeridin-1, and Caeridin-a1, were discovered from the skin secretion of the Australian White’s tree frog, Litoria caerulea, for the first time, by means of combining transcriptomic and peptidomic analyses.
It also represents the first report on bioactive Caeridins since this family of peptides was initially studied 20 years ago.
Chemically synthetic versions of each natural Caeridin demonstrated promising bioactivities either on rat smooth muscles or against microbial growth.
Specifically, Caeridin-1 produced contraction of rat bladder smooth muscle, while S5-Caeridin-1 induced relaxation of rat ileum smooth muscle, both at nanomolar concentrations.
Moreover, Caeridin-a1 was shown to potently inhibit the growth of the planktonic Gram-positive bacteria Staphylococcus aureus (S.
aureus), methicillin-resistant S.
aureus (MRSA), and Enterococcus faecalis (E.
faecalis), the Gram-negative bacterium, Escherichia coli (E.
coli), and the yeast, Candida albicans (C.
albicans).
The discovery of these Caeridins may induce further intensive and systematic studies of frog skin peptides to promote the discovery of natural templates as lead compounds for drug discovery and therapeutic application.
American Psychological Association (APA)
Li, Lei& Wu, Qing& Wang, Xi& Lu, Huimin& Xi, Xinping& Zhou, Mei…[et al.]. 2018. Discovery of Novel Caeridins from the Skin Secretion of the Australian White’s Tree Frog, Litoria caerulea. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1172875
Modern Language Association (MLA)
Li, Lei…[et al.]. Discovery of Novel Caeridins from the Skin Secretion of the Australian White’s Tree Frog, Litoria caerulea. International Journal of Genomics No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1172875
American Medical Association (AMA)
Li, Lei& Wu, Qing& Wang, Xi& Lu, Huimin& Xi, Xinping& Zhou, Mei…[et al.]. Discovery of Novel Caeridins from the Skin Secretion of the Australian White’s Tree Frog, Litoria caerulea. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1172875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172875