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Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass
Joint Authors
Mohsin, Sahar
Kaimala, Suneesh
Sunny, Jens Jolly
Adeghate, Ernest
Brown, Eric Mensah
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
T2DM is linked to an increase in the fracture rate as compared to the nondiabetic population even with normal or raised bone mineral density (BMD).
Hence, bone quality plays an important role in the pathogenesis of skeletal fragility due to T2DM.
This study analyzed the changes in the trabecular bone microstructure due to T2DM at various time points in ovariectomized and nonovariectomized rats.
Animals were divided into four groups: (I) control (sham), (II) diabetic (sham), (III) ovariectomized, and (IV) ovariectomized with diabetes.
The trabecular microarchitecture of the femoral head was characterized using a micro-CT.
The differences between the groups were analyzed at 8, 10, and 14 weeks of the onset of T2DM using a two-way analysis of variance and by post hoc multiple comparisons.
The diabetic group with and without ovariectomies demonstrated a significant increase in trabecular separation and a decrease in bone volume fraction, trabecular number, and thickness.
BMD decreased in ovariectomized diabetic animals at 14 weeks of the onset of T2DM.
No significant change was found in connectivity density and degree of anisotropy among groups.
The structural model index suggested a change towards a weaker rod-like microstructure in diabetic animals.
The data obtained suggested that T2DM affects the trabecular structure within a rat’s femoral heads negatively and changes are most significant at a longer duration of T2DM, increasing the risk to hip fractures.
American Psychological Association (APA)
Mohsin, Sahar& Kaimala, Suneesh& Sunny, Jens Jolly& Adeghate, Ernest& Brown, Eric Mensah. 2019. Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172896
Modern Language Association (MLA)
Mohsin, Sahar…[et al.]. Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172896
American Medical Association (AMA)
Mohsin, Sahar& Kaimala, Suneesh& Sunny, Jens Jolly& Adeghate, Ernest& Brown, Eric Mensah. Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172896