Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products
Joint Authors
Jo, Kyuhyung
Jung, Eunsoo
Kang, Wan Seok
Kim, Junghyun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The renal accumulation of advanced glycation end products (AGEs) is a causative factor of various renal diseases, including chronic kidney disease and diabetic nephropathy.
AGE inhibitors, such as aminoguanidine and pyridoxamine, have the therapeutic activities for reversing the increase in renal AGE burden.
This study evaluated the inhibitory effects of ethyl pyruvate (EP) on methylglyoxal- (MGO-) modified AGE cross-links with proteins in vitro.
We also determined the potential activity of EP in reducing the renal AGE burden in exogenously MGO-injected rats.
EP inhibited MGO-modified AGE-bovine serum albumin (BSA) cross-links to collagen (IC50=0.19±0.03 mM) in a dose-dependent manner, and its activity was stronger than aminoguanidine (IC50=35.97±0.85 mM).
In addition, EP directly trapped MGO (IC50=4.41±0.08 mM) in vitro.
In exogenous MGO-injected rats, EP suppressed AGE burden and MGO-induced oxidative injury in renal tissues.
These activities of EP on the MGO-mediated AGEs cross-links with protein in vitro and in vivo showed its pharmacological potential for inhibiting AGE-induced renal diseases.
American Psychological Association (APA)
Jung, Eunsoo& Kang, Wan Seok& Jo, Kyuhyung& Kim, Junghyun. 2019. Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172911
Modern Language Association (MLA)
Jung, Eunsoo…[et al.]. Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1172911
American Medical Association (AMA)
Jung, Eunsoo& Kang, Wan Seok& Jo, Kyuhyung& Kim, Junghyun. Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172911