Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection
Joint Authors
Meloni, Marco
Izzo, Valentina
Giurato, Laura
Brocco, Enrico
Uccioli, Luigi
Gandini, Roberto
Ferrannini, Michele
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI).
Materials and Methods.
The study group was composed of diabetic patients with DFI and CLI.
All patients were treated according to a preset limb salvage protocol which includes revascularization, wound debridement, antibiotic therapy, and offloading.
Inflammatory markers, including PCT, were evaluated at admission.
Only positive values of PCT, greater than 0.5 ng/ml, were considered.
Hospital outcomes were categorized as limb salvage (discharge with preserved limb), major amputation (amputation above the ankle), and mortality.
Results.
Eighty-six patients were included.
The mean age was 67.3±11.4 years, 80.7% were male, 95.1% had type 2 diabetes, and the mean diabetes duration was 20.5±11.1 with a mean HbA1c of 67±16 mmol/mol.
66/86 (76.8%) of patients had limb salvage, 7/86 (8.1%) had major amputation, and 13/86 (15.1%) died.
Patients with positive PCT baseline values in comparison to those with normal values showed a lower rate of limb salvage (30.4 versus 93.6%, p=0.0001), a higher rate of major amputation (13 versus 6.3%, p=0.3), and a higher rate of hospital mortality (56.5 versus 0%, p<0.0001).
At the multivariate analysis of independent predictors found at univariate analysis, positive PCT was an independent predictor of major amputation [OR 3.3 (CI 95% 2.0-5.3), p=0.0001] and mortality [OR 4.1 (CI 95% 2.2-8.3), p<0.0001].
Discussion.
Positive PCT at admission increased the risk of major amputation and mortality in hospital patients with DFI and CLI.
American Psychological Association (APA)
Meloni, Marco& Izzo, Valentina& Giurato, Laura& Brocco, Enrico& Ferrannini, Michele& Gandini, Roberto…[et al.]. 2019. Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172926
Modern Language Association (MLA)
Meloni, Marco…[et al.]. Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection. Journal of Diabetes Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1172926
American Medical Association (AMA)
Meloni, Marco& Izzo, Valentina& Giurato, Laura& Brocco, Enrico& Ferrannini, Michele& Gandini, Roberto…[et al.]. Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172926